Someone they left to die

so this quote when we learn a bit about BOE from john:

“What does BOE stand for?”
“Blood of Eden” he’d said, slowly
“Who is Eden?”
“Someone they left to die,” said God wearily. “How sharper than the serpent’s tooth, et cetera … Harrow, if you bother to remember anything from my ramblings, please remember this: once you turn your back on something, you have no more right to act as though you own it.”

So I’m curious about the theories around this one. The full quote is form King Lear and it finishes:

How sharper than a serpent’s tooth it is
To have a thankless child!

My personal one is that eden is referring to earth, and leaving it to die means abandoning it to the cataclysm that made john resurrect everyone, based on:
1. A (flimsy) Interpretation of “Eden” as “Paradise”
2. if they named themselves after something it must be important to them, and wake seemed pretty pissed about the extincion

The quote seems to be implying that john founded them.

Has this been said before? Anyone has a different theory? I’m pretty curious.