yo at p=009402 there's this dialogue "DAVE: so DAVE: you are my biological mother ROXY: yes DAVE: and roses ROXY: yes DAVE: and therefore bear at least partial and like biologically incidental responsibility for why we are both so fucked up." Do you have any idea what he means by "so fucked up"? thanks!

He could means like different? He could also be referencing illnesses as in Rose’s predisposition to addiction could have been passed on genetically from Roxy, Dave’s issues seem more environmentally based but he could also have had an underlying  mental condition that he inherited from Dirk.

But knowing Dave he was probably just making a joke about how parents are the reason for everything that’s wrong with their kids.