Yeah, uh. Not only does the wiki outright say it's canon (so no, other interpretations are really not valid, if you have an issue about that go talk to them), Karkat's ancestor was panquadrant as well, so when he says "I want someone in every quadrant" on top of all the foreshadowing and never retracts it, there's no reason to dismiss that.

voidfire said:    Also, offering a poly ship feat. two characters who both expressed wanting a monogamous partner (no, Dave literally said they broke up because he couldn’t handle her having someone “on the side”) especally one that erases their queer narritive (as well as Jade’s, but since when does anyone care about her expressed discomfort with it), as a ‘solution’ to a homophobe ranting about it, is kinda shitty, ngl   

 wow, okay, you are making way to big a deal about this, like chill out man, we’re talking about fictional characters smoochin, like geez