if johns group came first and cloned janes group from their guardians, meaning that janes group are their 'parents', does this mean that karkats group are kankris groups 'parents?'

Possibly? With Karkat’s group being the ones to actually do the ectobiology it’s not entirely known. It’s implied that Karkat’s group are the “parents” but it’s never stated outright so we can’t know for sure 100%.