A few parts of Homestuck were influenced by the 2001 movie Donnie Darko.
First off, the main character, Donnie, has a similar power to Trace, #3 of the Felt mob: Trace can see the past- and future-trails of people, and interact with people through them. Donnie can only see future trails, though. (See picture.)
Second, Donnie shares a similar appearance and personality to Karkat; he has messy hair, an almost groggy appearance, and a really really crabby attitude. Oh, and he gets pretty creative with his swears.
Third, Donnie’s mother (whose name is Rose), has a haircut fairly similar to Rose’s mother, and Roxy Lalonde. (This one is probably just a coincidence.)
Confirmation links, from the formspring archive, because Hussie’s old formspring doesn’t exist anymore: