Do you think that the personalities of the trolls would be altered at all as humans?

You mean for things like Humanstuck? Aside from proooobably not killing people as often, no. Nope, Vriska would still be a “8luh 8luh huge 8itch”, Karkat would be shouty, and Sollux would still be a computer guy. Motivations might change but if you change their personalities they aren’t even those characters at all any more.