Witches are know for curses. I think, Witch of Life would be able to lay a curse of Lycanthropy or some other curse of this kind. Maybe Heart or Blood would also be able to pull this off. Witch of Dood or Blood can curse someone to have their loved ones die. While Witch of Void, Time or Breath can lay something like "being forced to roam the world forever without being able to settle anywhere, without ever being a part of history". Not sure about others. Mind might make someone overthink tho

I mean, ‘Curses’ could work in the sense that they fall under the Witch’s ‘Changing’ realm, like, a spell that alters the nature of something Aspect-based on a person. I could see Space being more the Lycanthropy one though, but I see how Life would fit into it, it just feels a bit stretching it too far to change someone’s entire Biology like that? Although explained like that it does fall into the Life Witch’s realm.