how did doc mess up the frog? I thought karkat did

They rushed the Genesis Frog because they couldn’t find the Final Frog- Final Frog which Jade remembered having seen back on Earth for a moment when she was little. Jade mentions that after that event, she woke up on Prospit and her Grandpa had to build her robot, to which Kanaya replies she woke up after Doc Scratch appeared. It took me a LONG time to piece these things together, but Doc Scratch only influences the Trolls when he wants to make them do something that’d benefit him and Lord English. His visit was a sabotage- Kanaya woke up in an unnatural way, instead of waking up when she found the first Frog. The Red Universe was bound to be cancerous, because Doc Scratch never allowed Kanaya see the last Frog they needed to complete the genetic sequence.