Since its a fully customizable game, do the rules ever change from build a tall house, go through portals?

Nope, building, portals, gathering grist, going for the Denizens, the Battlefield battle, seem to all be Standard, but I mean. Lands, the Quest, the Alchemiter, the God Tiers, the people playing the Session and the million of things that can go differently and wrong, having a base doesn’t take from the customization.