You should be able to neuter anything with reproductive organs so I don’t see why not, but I asked a friend and they said “it would be easier to not introduce eggs because frogs fertilize after that fact, unless they’re freelance frogs” so I think you could neuter the genesis frog but how would you even neuter a universe?

This raises more questions like, how physical is the Genesis Frog? The Red Miles pierced into it and they just kind of. Passed through into the Universe. Does it have actual organs? Or is its body merely a gateway into the Universe, in the shape of a frog?